An excellent research article by Robert Zimmerleiter, Julian Kager, Ramin Nikzad-Langerodi, Vladimir Berezhinskiy, Frank Westad, Christoph Herwig & Markus Brandstetter in
Analytical and Bioanalytical Chemistry demonstrating the applicability of Spectral Engines' NIRONE Sensors in bioprocess monitoring. "The potential of non-invasive NIR spectroscopic measurements in reflection geometry through the glass wall of a bioreactor for real-time bioprocess monitoring was successfully demonstrated."
Summary of the article
The precise control of bioprocesses is essential to achieve optimum quality and yield of the desired product. A key to achieving this goal is analytical methods that provide real-time information about the current process state and critical process parameters.
One of the most promising sensing approaches for in-line application is near-infrared (NIR) and mid-infrared (MIR) spectroscopy, which, combined with multivariate data analysis, have been previously used for the real-time measurement of various process parameters.
The advantages of spectroscopic methods for bioprocess monitoring are manifold and include real-time capability, its non-destructive nature, easy maintenance, and the possibility for simultaneous determination of multiple target analytes in the complex fermentation broth.
With the recent advent of novel miniature spectrometer technology (“microspectrometer”) based on micro-electromechanical systems (MEMS), compact, robust, and cost-effective NIR spectrometers (NIRONE S, Spectral Engines Oy) became available and significantly lowered the hardware costs for multiple NIR sensing applications. This makes NIR spectroscopy much more attractive and creates the potential to enable completely new applications for the measurement technique.
The potential of non-invasive NIR spectroscopic measurements in reflection geometry through the glass wall of a bioreactor for real-time bioprocess monitoring was successfully demonstrated.
Reference:
Zimmerleiter, R., Kager, J., Nikzad-Langerodi, R. et al. Probeless non-invasive near-infrared spectroscopic bioprocess monitoring using microspectrometer technology. Anal Bioanal Chem (2019) doi:10.1007/s00216-019-02227-w.
Available online: https://link.springer.com/article/10.1007/s00216-019-02227-w
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